Drug development is the blanket term which is used to explain the complete process to bring new drugs into the market. One of the most important parts associated with the process of drug development is the drug discovery. There are several researches that need to be conducted. The two most important researches that take place while the process of the drug development are:
- Pre-clinical research
- Clinical Trials
Hence these are the two phases in which the drug development takes place. The physicochemical properties are established with drug development. The NCE and its metabolism, pharmacokinetics, toxicity and safety are duly checked.
Development of Liquid Formulation
The liquid formulations and their development are very important part of the drug development. The development of the liquid formulations such as syrups, cough syrups, inject able liquids, anima etc. the anima is inserted into the human body for therapeutic and investigative purposes. The emulsions are also a very important part the liquid formulations.
Development of Solid Formulation
The solid formulation and development is the dimension of drug development that includes the formulation of all solid medicines. The solid medicines would include the tablets as well as the capsules. There are various types of tablets that are formulated and developed in the process of drug development. The same is applicable for the capsules as well.
Immediate Release tablets
The formulation and development of the immediate release tablets need particular specifications. These specifications are very important for the formulation of the immediate release tablets. The job of the immediate release tablets is to start their action instantly once swallowed. The tablets that are for immediate release are indicated with the symbol of IR.
Sustained Release tablets
The sustained release tablets are the tablets that are formulated with an aim to have their effect for a longer period. These tablets are indicated with the symbol of SR. The sustained release tablets take time to dissolve in the body and are released slower. The sustained releases tablets used to have different dosage than the immediate release tablets.
The active substance when enclosed in a gelatinous envelope is known as a capsule. Once ingested, these capsules used to remain intact inside the body for few hours. This results in delay in the absorption of the medicine. You can find capsules of both immediate release as well as sustained release. You may find the different releases in the same dosage.
Formulation of Topical medications
The topical medications are of several forms. Some of the forms of the topical medications are as follows:
- Powder – A powder is the solid substance that is finely subdivided.
- Paste – The paste combines powder, water, and oil.
- Gel – The gel liquefies upon coming into contact to the skin.
- Ointment – This is the topical medications that combine 80% of oil and 20% of water. The ointment works as a barrier against the moisture loss.
- Cream – The emulsion of the water and oil in approximately similar proportions.
All the above are the typical forms of topical medications.
Formulation of Dry Granulations
During the dry granulations of the drug development the size of the particles is checked. The stability, dissolution times, content uniformity all these factors are checked while the dry granulation.
Formulation of wet granulations
During the wet granulations the adhesives or liquid binders are added with lactose as well as active mixture. This mixture is once dried then sized. Once sized the dried mixture is transformed into tablets.
Stieg Larsson has been associated with the Drug Development Services for several years now. His knowledge and experience both are tremendously effective and appreciable. His Blog has all the updates.