Reducing Gastric Emptying Rate May be the Key to Obesity Prevention

July 3, 2012


Reducing Gastric Emptying Rate May be the Key to Obesity Prevention

Obesity Prevention

Obesity Prevention

There are a lot of weight loss remedies that are being recommended, but most of them are not 100% effective in making you lose weight. If you are one of those who are constantly searching for an effective tool in avoiding gaining weight, the result of a recent study may jut be your answer.

A recent research has just discovered a possible way of preventing obesity through suppression of food intake and hunger. This is through a hormone that acts to slow down the gastric emptying time or the time that the stomach empties from food content.

The study was an animal-based study that was presented on the 94th Annual Meeting of the Endocrine Society in Houston. The study revealed a hormone in the gut that acts as a neurotransmitter that slows down the gastric emptying time by inhibiting the receptors in the brain related to gastric emptying. This hormone was known as GLP-2 or glucagon-like peptide 2.

The inhibition of the gastric emptying time was found to be linked to the action of the GLP-2 on its receptor sites in the brain. The receptors sites were found mainly on the POMC neurons or the pro-opiomelanocortin neurons in the hypothalamus, which is the appetite-controlling center of the brain.

The research involved the use of mice. There were two groups of mice used–one group with GLP-2 receptors and the other group consisted of mice lacking these GLP-2 receptors. The study revealed that mice that lack the GLP-2 receptor had higher food intake and had late-onset obesity as compared to mice that have the receptors in their brain.

The group of mice that did not have the GLP-2 receptors also had accelerated gastric emptying time leading to a higher food intake because of feeling of being hungry quickly even after meals. The gastric emptying time was assessed using the non-invasive breath test that allows detecting presence of food in the stomach.

The GLP-2 receptor is also present in humans. Obese people may have something defective on this hormone, which prevents slowing down of the gastric emptying time. Aside from these results, it was also seen that the GLP-2 receptor also hastens the activation of the P13K intracellular signaling in the hypothalamus; thus acts in an important pathway for gastric emptying and hunger.

The results of the study further concluded that there is a brain-gut circuit in the neurons, which means that the manner we eat may be directly affected by the neural signaling in the brain.

There are still no further studies on how do we get this GLP-2 hormone to prevent weight gaining and obesity, but the knowledge that delayed gastric emptying prevents obesity may still be implemented through consumption of foods that are harder to digest. Consuming slow-digesting foods such as whole grains, red rice, brown rice and whole wheat bread and pasta promotes slowed gastric emptying, which prevents hunger and food cravings.

Aside from these, it is also essential that people who want to lose weight should begin practicing healthy lifestyle such as proper food intake instead of dealing with low calorie diet. Low calorie diet allows you to feel hungry most of the time that leads to more food cravings and binge eating.

Guest Author Bio

Dr. Amarendra is a health and fitness enthusiast who likes to share his views on weight loss products like Medifast and Nutrisystem. Learn more about them by visiting this url.


Reducing Gastric Emptying Rate May be the Key to Obesity Prevention

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Obesity Prevention

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